| To synthesize a platinum-based anti-tumor drug picoplatin, the key intermediate K[Pt(NH3)Cl3] , synthesized from ammonium acetate and K2PtCl4 was subsequently reacted with KI, 2-picoline, AgNO3 and KCl to give the target compound. The structure and component were characterized by elemental analysis, ESI-MS, 1H-NMR and IR. The results showed that its structure was consistent with the title compound and the yield was about 40%. This provides a new process for the synthesis of picoplatin. |
