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| PDA@Ag纳米复合材料的制备及抑菌性能研究 |
| Study on preparation and antibacterial property of PDA@Ag composite nanomaterials |
| 投稿时间：2020-05-27 |
| DOI： |
| 中文关键词: 复合材料 核@壳结构 纳米银 原位还原 抑菌机理 |
| 英文关键词: composite materials core@shell structure nano-silver in situ reduction antimicrobial mechanism |
| 基金项目:陕西省科技创新基地建设项目(2021ZY2-JD- 09)；陕西省重点研发计划项目(2020NY-062)；陕西省教育厅科技计划项目(21JK0565) |
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| 中文摘要: |
| 以多巴胺为原料，在碱性条件下通过自聚合制备聚多巴胺(PDA)亚微球，将银离子(Ag+)原位还原为银(Ag)，负载在亚微球表面合成核壳型纳米PDA@Ag复合材料。采用透射电镜(TEM)、X射线衍射(XRD)、紫外-可见漫反射光谱(UV-Vis DRS)、X射线光电子能谱(XPS)和热重分析(TGA)对其进行表征，结果表明合成了核壳型PDA@Ag复合材料，吸附在亚微球表面的纳米银尺寸约为25 nm。以金黄色葡萄球菌(S. aureus)和大肠杆菌(E. coli)为模式菌，用纳米银作参比，比较其抑菌活性。结果表明，PDA@Ag比纳米银具有更优异的抑菌性能，且对细胞壁中含有少量的磷脂双分子层的大肠杆菌更为敏感。 |
| 英文摘要: |
| Polydopamine (PDA) sub-micrometer spheres were prepared by using dopamine as raw material via self-polymerization under the alkaline conditions. Then, PDA@Ag composite nanomaterials with core-shell structure were synthesized by in-situ reduction of Ag+, in which silver nanoparticles were assembled on the surface of PDA spheres. The nanocomposites were characterized by transmission electron microscope (TEM), X-ray powder diffraction (XRD), UV-Vis diffuse reflectance spectra (DRS), X-ray photoelectron spectrometry (XPS), thermo gravimetric analysis (TGA). The results showed that the core-shell PDA@Ag composite was synthesized, and that the size of silver nanoparticles adsorbed on the submicrosphere was about 25 nm. The antibacterial activity of PDA@Ag against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) was evaluated using Ag nanoparticles as reference. The results revealed that PDA@Ag had excellent antibacterial property and was more sensitive to E. coli than to S. aureus, because E. coli has less amount of phospholipid bilayer than S. aureus in cell wall |
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