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铂类抗肿瘤药物甲啶铂的水合反应研究 |
The Study of Aquation of Picoplatin, a Platinum-based Anti-tumor Drug |
投稿时间:2014-02-21 |
DOI: |
中文关键词: 药物化学 抗肿瘤药物 甲啶铂 水合反应 一级反应 |
英文关键词: medicinal chemistry platinum-based anti-tumor drug picoplatin aquation the first-order reaction |
基金项目:云南省科技厅重点新产品开发计划“抗肿瘤化学I类新药甲啶铂注射液的临床前预研究”(2013BC010)。 |
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中文摘要: |
采用高效液相色谱研究了抗肿瘤药物甲啶铂的水合反应,以及甲啶铂在0.9% NaCl溶液中的稳定性。结果表明,甲啶铂的水合反应遵循一级反应动力学规律,20℃时反应速率常数为k=0.03086 h-1,半衰期22.5 h,反应活化能E=80.6 kJ/mol;在0.9% NaCl溶液中,甲啶铂的水合反应被抑制,反应达到平衡后,甲啶铂的降解不超过4%。 |
英文摘要: |
HPLC analytical method was used to investigate the aquation of picoplatin, and the stability of picoplatin in 0.9% NaCl solution. The results show that the aquation of picoplatin followed the law of the first-order reaction, the rate constant was 0.03086 h-1, the half life period was 22.5 h, the activation energy was 80.6 kJ/mol. Picoplatin is stable in 0.9% NaCl solution, the degradation did not exceed 4% when the reaction achieved balance. |
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