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| 新型铂(Ⅱ)类配合物的合成、表征和抗肿瘤活性 |
| Synthesis, Characterization and Antitumor Activities of Platinum(II) Complexes |
| Received:April 03, 2013 |
| DOI： |
| 中文关键词: 有机化学 铂配合物 合成 表征 抗癌活性 |
| 英文关键词: organic chemistry platinum complex synthesis characterization antitumor activity |
| 基金项目:云南省科技条件平台建设项目(2010DH021) |
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| 中文摘要: |
| 合成了以甲胺/环戊胺为伴随基团，分别以氯离子、1,1-环丁基二羧酸根和草酸根作为离去基团的3种新的铂(II)配合物。以顺-二碘-二环戊胺合铂(II)、硝酸银、甲胺、氯化钾、1,1-环丁基二羧酸钾和草酸钾为原料合成目标化合物。采用元素分析、质谱、核磁共振氢谱和红外光谱分析其组成和结构，利用MTT体外检测法进行了初步的体外活性评价，表明合成的3种化合物结构与理论一致，具有一定的体外肿瘤生长抑制活性。 |
| 英文摘要: |
| Three kinds of mixed methylamine/cyclopentylamine platinum(II) complexes were obtained with chloride, cyclobutane-1,1-dicarboxylic acid and oxalic acid ions as leaving groups respectively. The title compounds were synthesized from cis-(C5H11N)2PtI2, silver nitrate, methylamine, potassium chloride, potassium cyclobutane-1,1-dicarboxylic, potassium oxalate monohydrate as raw materials. The complex structure and component were characterized by elemental analysis, ESI-MS, 1H-NMR and IR, and the anticancer activities were measured by MTT method. The results showed that their structures were consistent with the title compounds and had inhibiting effects on the growth of tumor cell lines in vitro. |
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