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| 抗肿瘤新药甲啶铂的合成工艺研究 |
| A New Synthetic Method of Picoplatin, An Antitumor Drug |
| Received:February 22, 2013 |
| DOI： |
| 中文关键词: 有机化学 铂配合物 甲啶铂 合成 |
| 英文关键词: organic chemistry platinum complex picoplatin synthesis |
| 基金项目:云南省科技计划资助项目(2010DH021)。 |
| Author Name | Affiliation | E-mail | | WANG Qingkun | Yunnan Engineering and Technology Center of Platinum-based Anti-tumor Drug,Kunming Guiyan Pharmaceutical Co. Ltd., Kunming 650106, China | jrss1979@163.com | | PU Shaoping | Yunnan Engineering and Technology Center of Platinum-based Anti-tumor Drug,Kunming Guiyan Pharmaceutical Co. Ltd., Kunming 650106, China | pushaoping@163.com | | HE Jian | Yunnan Engineering and Technology Center of Platinum-based Anti-tumor Drug,Kunming Guiyan Pharmaceutical Co. Ltd., Kunming 650106, China | | | LIU Liangmeng | Yunnan Engineering and Technology Center of Platinum-based Anti-tumor Drug,Kunming Guiyan Pharmaceutical Co. Ltd., Kunming 650106, China | | | LIAO Yunxing | Yunnan Engineering and Technology Center of Platinum-based Anti-tumor Drug,Kunming Guiyan Pharmaceutical Co. Ltd., Kunming 650106, China | | | JIN Jie | Yunnan Engineering and Technology Center of Platinum-based Anti-tumor Drug,Kunming Guiyan Pharmaceutical Co. Ltd., Kunming 650106, China | |
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| 中文摘要: |
| 为合成抗肿瘤药物甲啶铂，采用醋酸铵与K2PtCl4反应生成K[Pt(NH3)Cl3]，再先后与碘化钾、2-甲基吡啶、硝酸银、氯化钾反应生成甲啶铂。采用元素分析、质谱、核磁共振氢谱和红外光谱对其结构进行了表征。结果显示合成的化合物与理论一致，产率约为40%，可为甲啶铂的合成提供一条新的工艺路线。 |
| 英文摘要: |
| To synthesize a platinum-based anti-tumor drug picoplatin, the key intermediate K[Pt(NH3)Cl3] , synthesized from ammonium acetate and K2PtCl4 was subsequently reacted with KI, 2-picoline, AgNO3 and KCl to give the target compound. The structure and component were characterized by elemental analysis, ESI-MS, 1H-NMR and IR. The results showed that its structure was consistent with the title compound and the yield was about 40%. This provides a new process for the synthesis of picoplatin. |
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