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| 顺式-甲基丙二酸-二氨合铂(II)的合成、表征及抗癌活性 |
| Synthesis, Characterization and Antitumor Activity of |
| Received:March 20, 2013 |
| DOI： |
| 中文关键词: 有机化学 铂配合物 甲基丙二酸 合成 抗癌活性 |
| 英文关键词: organic chemistry platinum complex methylmalonic acid synthesis antitumor activity |
| 基金项目:云南省重点科技计划项目(2010DH021)。 |
| Author Name | Affiliation | E-mail | | ZHU Zebing | Yunnan Engineering and Technology Center of Platinum-based Anti-tumor Drug, Kunming Guiyan Pharmaceutical Co.Ltd., Kunming 650106, China | zhu99726@chinaren.com | | WANG Qingkun | Yunnan Engineering and Technology Center of Platinum-based Anti-tumor Drug, Kunming Guiyan Pharmaceutical Co.Ltd., Kunming 650106, China | | | XU Honghua | Yunnan Engineering and Technology Center of Platinum-based Anti-tumor Drug, Kunming Guiyan Pharmaceutical Co.Ltd., Kunming 650106, China | | | PU Shaoping | Yunnan Engineering and Technology Center of Platinum-based Anti-tumor Drug, Kunming Guiyan Pharmaceutical Co.Ltd., Kunming 650106, China | pushaoping@163.com | | CONG Yanwei | Yunnan Engineering and Technology Center of Platinum-based Anti-tumor Drug, Kunming Guiyan Pharmaceutical Co.Ltd., Kunming 650106, China | | | BEI Yuxiang | Yunnan Engineering and Technology Center of Platinum-based Anti-tumor Drug, Kunming Guiyan Pharmaceutical Co.Ltd., Kunming 650106, China | | | HUANG Tianjun | Yunnan Engineering and Technology Center of Platinum-based Anti-tumor Drug, Kunming Guiyan Pharmaceutical Co.Ltd., Kunming 650106, China | | | MIAO Xianghong | Yunnan Engineering and Technology Center of Platinum-based Anti-tumor Drug, Kunming Guiyan Pharmaceutical Co.Ltd., Kunming 650106, China | |
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| 中文摘要: |
| 为合成新的铂配合物顺式-甲基丙二酸-二氨合铂(II)，以顺式二碘-二氨合铂(II)为起始原料，先后与硝酸银和甲基丙二酸反应合成目标化合物。采用元素分析、质谱、核磁共振氢谱和红外光谱分析其组成和结构，采用MTT法对配合物进行了初步的体外活性评价。结果显示合成的化合物结构与理论一致，具有一定的体外肿瘤生长抑制活性。 |
| 英文摘要: |
| Cis-diammine (methylmalonato)platinum(II), a platinum anticancer compound, was synthesized via the reaction of cis-diiododiaminoplatinum(II) with silver nitrate and characterized by elemental analysis, ESI-MS, 1H-NMR and IR. The in vitro anticancer activity was measured by MTT method. The results showed that its structure was consistent with the title compound and had inhibitory effect on the growth of tumor cell lines. |
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