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| 卡铂在多壁碳纳米管玻碳电极上的电化学行为及测定的研究 |
| Study on the Electrochemical Behavior of Carboplatin at Multi-walled Carbon Nanotubes Modified Glassy Carbon Electrode and the Determination of Carboplatin |
| Received:March 04, 2013 |
| DOI： |
| 中文关键词: 分析化学 卡铂 多壁碳纳米管 电极 电化学行为 伏安法 |
| 英文关键词: analytical chemistry carboplatin multi-walled carbon nanotubes electrode electrochemical behavior voltammetry |
| 基金项目:云南省创新团队计划(2011HC008)、云南省高校科技创新团队计划项目(2011UY09)。 |
| Author Name | Affiliation | E-mail | | YE Liqing | Key Laboratory of Ethnic Medicine Resource Chemistry, State Ethnic Affairs Commission & Ministry of Education, College of Chemistry and Biotechnology, Yunnan University of Nationalities, Kunming 650500, China | budian667@126.com | | PU Shaoping | Kunming Guiyan Pharmaceutical Co.Ltd., Kunming 650106, China | | | FANG Maoliang | Key Laboratory of Ethnic Medicine Resource Chemistry, State Ethnic Affairs Commission & Ministry of Education, College of Chemistry and Biotechnology, Yunnan University of Nationalities, Kunming 650500, China | | | GAO Yuntao | Key Laboratory of Ethnic Medicine Resource Chemistry, State Ethnic Affairs Commission & Ministry of Education, College of Chemistry and Biotechnology, Yunnan University of Nationalities, Kunming 650500, China | yuntaogao@sohu.com | | BEI Yuxiang | Kunming Guiyan Pharmaceutical Co.Ltd., Kunming 650106, China | | | YAN Lili | Key Laboratory of Ethnic Medicine Resource Chemistry, State Ethnic Affairs Commission & Ministry of Education, College of Chemistry and Biotechnology, Yunnan University of Nationalities, Kunming 650500, China | |
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| 中文摘要: |
| 采用循环伏安法(CV)和差分脉冲伏安法(DPV)，研究了卡铂在多壁碳纳米管玻碳电极(MWCNTs/GCE)上的电化学行为并建立了卡铂的测定方法。结果表明:卡铂在多壁碳纳米管玻碳电极上有一对氧化还原峰，氧化峰电位Epa与还原峰电位Epc分别为0.73 V、0.26 V，峰电位之差为ΔE=0.47 V，Ipa/Ipc=1.57。在优化条件下，卡铂的氧化峰电流与其浓度在0.22~0.67 mmol/L范围内成良好的线性关系(r=0.9942)，检出限为0.2 mmol/L。方法操作简便，准确可靠、灵敏度高，可用于卡铂含量的直接测定。 |
| 英文摘要: |
| The electrochemical behavior of carboplatin at multi-walled carbon nanotubes modified glassy carbon electrode was investigated by cyclic voltammetry and differential pulse voltammetry, and a new method was established for the determination of carboplatin. The results show that one pair of redox peaks of carboplatin with 0.73 V of Epa and 0.26 V of Epc (ΔE=0.47 V，and Ipa/Ipc=1.57) was obtained at multi-walled carbon nanotubes modified glassy carbon electrode by cyclic voltammetry. Under the optimal conditions, the oxidization peak was linearly related to the concentration of carboplatin in the range of 0.22~0.67 mmol/L with the detection limit of 0.2 mmol/L. The method was convenient, accurate, credible and sensitive, and can be used in the determination of carboplatin. |
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