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| 顺式-水杨酸-(反式-(-)-1,2-环己二胺)合铂(II)的合成、表征及抗肿瘤活性 |
| Synthesis, Characterization and Antitumor Activities of Cis-salicylicacid- [trans-(-)-1,2-cyclohexanediamine] Platinum(II) |
| Received:October 28, 2013 |
| DOI： |
| 中文关键词: 有机化合物 铂配合物 水杨酸 合成 抗癌活性 |
| 英文关键词: organic compound platinum complex salicylic acid synthesis antitumor activity |
| 基金项目:云南省重点科技计划项目(2010DH021)。 |
| Author Name | Affiliation | E-mail | | ZHU Zebing | Yunnan Engineering and Technology Center of Platinum-based Anti-tumor Drug, Kunming Guiyan Pharmaceutical Co.Ltd., Kunming 650106, China | | | JIN Quan | Yunnan Engineering and Technology Center of Platinum-based Anti-tumor Drug, Kunming Guiyan Pharmaceutical Co.Ltd., Kunming 650106, China | | | XU Honghua | Yunnan Institute of Materia Medica, Kunming 650111, China | | | PU Shaoping | Yunnan Engineering and Technology Center of Platinum-based Anti-tumor Drug, Kunming Guiyan Pharmaceutical Co.Ltd., Kunming 650106, China | pushaoping@163.com | | WANG Qingkun | Yunnan Engineering and Technology Center of Platinum-based Anti-tumor Drug, Kunming Guiyan Pharmaceutical Co.Ltd., Kunming 650106, China | | | LI Xuejie | Yunnan Engineering and Technology Center of Platinum-based Anti-tumor Drug, Kunming Guiyan Pharmaceutical Co.Ltd., Kunming 650106, China | | | WEN Zhishou | Yunnan Engineering and Technology Center of Platinum-based Anti-tumor Drug, Kunming Guiyan Pharmaceutical Co.Ltd., Kunming 650106, China | | | WANG Meng | Yunnan Engineering and Technology Center of Platinum-based Anti-tumor Drug, Kunming Guiyan Pharmaceutical Co.Ltd., Kunming 650106, China | |
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| 中文摘要: |
| 用顺式-二碘-(反式-(-)-1,2-环己二胺)合铂(II)先后与硝酸银和水杨酸反应，制备得到新的铂配合物顺式-水杨酸-(反式-(-)-1,2-环己二胺)合铂(II)。采用元素分析、质谱、核磁共振氢谱和红外光谱等方法分析了其组成和结构，采用SRB比色法对配合物进行了初步体外活性评价。结果显示合成的化合物结构与理论一致，化合物对肺癌细胞株(A549)和口腔表皮样癌细胞株(KB)的IC50值分别为2.3和3.1 μg∕mL。 |
| 英文摘要: |
| In order to obtain a salicylic acid platinum complex, the title compound was synthesized from (1R,2R)-1,2-cyclohexanediamine-N,N'' platinum(II) diiodide by reacting with silver nitrate and salicylic acid. The complex structure and component were characterized by elemental analysis, ESI-MS, 1H-NMR and IR, and the anticancer activity was measured by SRB method. The results showed that its structure was consistent with the title compound and the IC50 value was 2.3 and 3.1 μg∕mL against A549 and KB cell lines. |
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