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| 铂类抗肿瘤药物甲啶铂的水合反应研究 |
| The Study of Aquation of Picoplatin, a Platinum-based Anti-tumor Drug |
| Received:February 21, 2014 |
| DOI： |
| 中文关键词: 药物化学 抗肿瘤药物 甲啶铂 水合反应 一级反应 |
| 英文关键词: medicinal chemistry platinum-based anti-tumor drug picoplatin aquation the first-order reaction |
| 基金项目:云南省科技厅重点新产品开发计划“抗肿瘤化学I类新药甲啶铂注射液的临床前预研究”(2013BC010)。 |
| Author Name | Affiliation | E-mail | | CHEN Hong | State Key Laboratory Advanced Technologies of Comprehensive Utilization of Platinum Metals, Kunming Institute of Precious Metals, Kunming 650106, China
Yunnan Engineering and Technology Center of Platinum-based Anti-tumor Drug,Kunming Guiyan Pharmaceutical Co.Ltd., Kunming 650106, China | | | LUAN Chunfang | Yunnan Engineering and Technology Center of Platinum-based Anti-tumor Drug,Kunming Guiyan Pharmaceutical Co.Ltd., Kunming 650106, China | | | CONG Yanwei | Yunnan Engineering and Technology Center of Platinum-based Anti-tumor Drug,Kunming Guiyan Pharmaceutical Co.Ltd., Kunming 650106, China | | | ZHANG Qi | Yunnan Engineering and Technology Center of Platinum-based Anti-tumor Drug,Kunming Guiyan Pharmaceutical Co.Ltd., Kunming 650106, China | | | PU Shaoping | Yunnan Engineering and Technology Center of Platinum-based Anti-tumor Drug,Kunming Guiyan Pharmaceutical Co.Ltd., Kunming 650106, China | pushaoping@163.com |
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| 中文摘要: |
| 采用高效液相色谱研究了抗肿瘤药物甲啶铂的水合反应，以及甲啶铂在0.9% NaCl溶液中的稳定性。结果表明，甲啶铂的水合反应遵循一级反应动力学规律，20℃时反应速率常数为k=0.03086 h-1，半衰期22.5 h，反应活化能E=80.6 kJ/mol；在0.9% NaCl溶液中，甲啶铂的水合反应被抑制，反应达到平衡后，甲啶铂的降解不超过4%。 |
| 英文摘要: |
| HPLC analytical method was used to investigate the aquation of picoplatin, and the stability of picoplatin in 0.9% NaCl solution. The results show that the aquation of picoplatin followed the law of the first-order reaction, the rate constant was 0.03086 h-1, the half life period was 22.5 h, the activation energy was 80.6 kJ/mol. Picoplatin is stable in 0.9% NaCl solution, the degradation did not exceed 4% when the reaction achieved balance. |
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