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| ((R)-(-)-1,2-丙二胺)(1,3-丙二酸)合铂(II)的合成、表征及抗肿瘤活性研究 |
| Synthesis, Characterization and Anticancer Activity of ((R)-(-)-1,2-diaminepropane)(1,3-malonate) Platinum(II) |
| Received:November 20, 2013 |
| DOI： |
| 中文关键词: 药物化学 1,2-丙二胺 铂配合物 合成 表征 抗肿瘤活性 |
| 英文关键词: medicinal chemistry 1,2-diaminepropane platinum complex synthesis characterization antitcancer activity. |
| 基金项目:昆明市重点科技计划项目(昆科计字2012-03-01-B-H-04-0006)。 |
| Author Name | Affiliation | E-mail | | CONG Yanwei | Kunming Guiyan Pharmaceutical Co.Ltd., Kunming 650106, China | | | CHEN Hong | Kunming Guiyan Pharmaceutical Co.Ltd., Kunming 650106, China
Kunming Institute of Precious Metals, Kunming 650106, China | | | LUAN Chunfang | Kunming Guiyan Pharmaceutical Co.Ltd., Kunming 650106, China | | | BAI Xinjie | Kunming Guiyan Pharmaceutical Co.Ltd., Kunming 650106, China | | | PU Shaoping | Kunming Guiyan Pharmaceutical Co.Ltd., Kunming 650106, China | pushaoping@163.com |
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| 中文摘要: |
| 以1,2-丙二胺为起始原料，经手性拆分得到R-(-)-1,2-丙二胺，再同氯亚铂酸钾、碘化钾、硝酸银、1,3-丙二酸钠等物质反应，制成((R)-(-)-1,2-丙二胺)(1,3-丙二酸)合铂(II)，通过元素分析、红外光谱、核磁共振等对其进行化学结构确证，结果表明所合成产品同理论一致，并进行初步体外活性评价，表明该化合物对于肺癌A-549及白血病HL-60肿瘤细胞有一定活性。 |
| 英文摘要: |
| (R)-(-)-1,2diaminepropane was obtained by rotation resolution of 1,2-diaminepropane as the starting material, and then was reacted with potassium tetrachloroplatinate, potassium iodide, silver nitrate, sodium 1,3-malonate to produce ((R)-(-)-1,2-diaminepropane)(1,3-malonate) platinum(II). Elemental analysis, infrared and nuclear magnetic resonance were used to characterize its chemical structure. Preliminary in vitro anticancer test showed that the complex was active against A-549 and HL-60 cancer cell line. |
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