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| 新型抗肿瘤洛铂衍生物LLC-1903的氢谱解析 |
| Explanation of 1H NMR Spectra of LLC-1903, a New Anticancer Lobaplatin Derivative |
| Received:June 15, 2016 |
| DOI： |
| 中文关键词: 分析化学 洛铂衍生物 1H NMR 归属 |
| 英文关键词: analytical chemistry lobaplatin 1H NMR assignments |
| 基金项目:国家自然科学基金项目(21661018)、云南省新药科技专项(2014BC010、2016BC021)。 |
| Author Name | Affiliation | E-mail | | GAO Anli | State key Laboratory of Advanced Technologies for Comprehensive Utilization of Platinum Metals, Kunming Institute ofPrecious Metals, Kunming 650106, China | gaoanli@126.com | | YANG Zhi | Yunnan Bai Yao Group Innovation and R&D Center, Kunming 650111, China | | | YANG Xiaoyan | Yunnan Bai Yao Group Innovation and R&D Center, Kunming 650111, China | | | JIANG Jing | State key Laboratory of Advanced Technologies for Comprehensive Utilization of Platinum Metals, Kunming Institute ofPrecious Metals, Kunming 650106, China | dianaair@126.com | | LIU Weiping | State key Laboratory of Advanced Technologies for Comprehensive Utilization of Platinum Metals, Kunming Institute ofPrecious Metals, Kunming 650106, China | |
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| 中文摘要: |
| 测定了新型抗肿瘤洛铂衍生物cis-[trans-1,2-双(氨甲基)环丁烷.3-氧代-1,1-环丁烷二羧酸合铂(II)](LLC-1903)在D2O和DMSO-d6中的1H NMR，并进行比较、分析和归属。对2种溶剂中的1H NMR谱图差异进行了解释，提出在水溶液中由于氢键的形成，导致在环丁烷上的2组CH2处于不同的空间位置，氢谱出现明显的分裂。 |
| 英文摘要: |
| A new derivative of lobaplatin, cis-[trans-1,2-bis(aminomethyl)cyclobutane.3-oxo-1,1-cyclo- butanedicarboxylatoplatinum(II) (LLC-1903), was characterized by nuclear magnetic resonance technology. 1H NMR spectra of the complex both in D2O and DMSO-d6 were compared and assigned. The differences of the spectra in D2O and DMSO-d6 were explained. It is proposed that the pronounced spilt observed in D2O for 1H peak of CH2 groups of 3-oxo-1,1-cyclobutanedicarboxylate should be caused by different spatial orientations of the CH2 groups in the molecule when the complex is dissolved in water, and a hydrogen bond ring may be formed by linking H2O with the oxygen of 3-carbonyl group and 1-carboxylate together, leading to distortion of the cyclobutane ring. |
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