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| 一种中空金/银双金属纳米颗粒的制备及其SERS性能 |
| Fabrication of Ag/Au Hollow Bimetallic Nanoparticles and Their SERS Property |
| Received:January 19, 2018 |
| DOI： |
| 中文关键词: 金/银双金属纳米颗粒 表面增强拉曼光谱 苯硫酚 atto610标记生物素 亲和素 |
| 英文关键词: Ag/Au nanoparticles SERS thiophenol atto610 labeled biotin avidin |
| 基金项目:国家自然科学基金(21505079)、南通市工业创新(MS12016039)、江苏省大学生创新训练(201610304085X、201710304099X)。 |
| Author Name | Affiliation | E-mail | | LIU Zhengyi | School of Chemistry and Chemical Engineering, Nantong University, Nantong 226019, Jiangsu, China | 1076353169@qq.com | | DU Jingjing | School of Chemistry and Chemical Engineering, Nantong University, Nantong 226019, Jiangsu, China | | | RAO Yan | School of Chemistry and Chemical Engineering, Nantong University, Nantong 226019, Jiangsu, China | | | ZHANG Jing | School of Chemistry and Chemical Engineering, Nantong University, Nantong 226019, Jiangsu, China | | | ZHAO Weiwen | School of Chemistry and Chemical Engineering, Nantong University, Nantong 226019, Jiangsu, China | | | WANG Qiwei | School of Chemistry and Chemical Engineering, Nantong University, Nantong 226019, Jiangsu, China | | | GU Xuefang | School of Chemistry and Chemical Engineering, Nantong University, Nantong 226019, Jiangsu, China | xuefang818@ntu.edu.cn | | TIAN Shu | School of Chemistry and Chemical Engineering, Nantong University, Nantong 226019, Jiangsu, China | |
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| 中文摘要: |
| 以银纳米颗粒为牺牲模板，利用Ag和HAuCl4之间的置换反应，结合柠檬酸钠同步还原的方法制备了一种中空金/银双金属纳米颗粒。通过对颗粒形貌及局域表面等离子体共振(LSPR)的分析，初步研究了此类金/银纳米颗粒的生长机理，并对影响反应的因素进行了探讨。结果表明，通过控制反应条件可以实现对LSPR的精密调控。该类金/银双金属纳米颗粒可用作为SERS基底，苯硫酚在其表面增强因子可达107，并具有良好的信号重现性。该基底用于atto610标记的生物素与亲和素的SERS检测，检测限可达80 pg/mL。 |
| 英文摘要: |
| A novel strategy based on the galvanic replacement reaction (between Ag and HAuCl4) and the coreduction of Ag+ (by sodium citrate) was proposed for the formation of Au/Ag hollow nanoparticles. In the process of synthesis, silver nanoparticles were used as sacrificial templates. The growth mechanism of such Au/Ag hollow nanoparticles was preliminarily investigated by analyzing their morphology and localized surface plasmon resonance (LSPR). The effects of the pipetting mode, the reaction temperature and the amount of reducing agent on the reaction were also discussed. The result shows that, by controlling the proper reaction condition, the SPR of Au/Ag nanoparticles from visible to near infrared region can be precisely modulated. Surface-enhanced Raman scattering (SERS) spectra of thiophenol on Au/Ag nanoparticle substrate were measured, and the enhancement factors could be as high as the value of 107. In addition to the significant SERS activity, signals were found excellent repeatability on this Au/Ag nanoparticle substrate. The substrate was further used for the SERS detection of avidin through the recognition between avidin and atto610 labeled biotin. Avidin could be detected over a wide concentration range and the detection limit was 80 pg/mL. |
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