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| 甲基丙二酸-(反式-1,2-二甲胺基环丁烷)合铂(II)的合成、结构及抗肿瘤活性 |
| Synthesis, Structure and Antitumor Activity of Methyl Malonic Acid- [trans-1,2-dimethylamino cyclobutane] Platinum(II) Compound |
| Received:September 02, 2019 |
| DOI： |
| 中文关键词: 药物化学 铂化合物 合成 结构 抗肿瘤活性 |
| 英文关键词: pharmaceutical chemistry platinum compound synthesis structure inhibitory activity |
| 基金项目:云南省科技创新平台建设计划(2016DH008) |
| Author Name | Affiliation | E-mail | | LI Jun | State Key Laboratory of Advanced Technologies for Comprehensive Utilization of Platinum Metals,Kunming Institute of Precious Metals, Kunming 650106, China
Yunnan Engineering and Technology Center of Platinum-based Anti-tumor Drug,Kunming Guiyan Pharmaceutical Co.Ltd., Kunming 650106, China | | | CONG Yanwei | Yunnan Engineering and Technology Center of Platinum-based Anti-tumor Drug,Kunming Guiyan Pharmaceutical Co.Ltd., Kunming 650106, China | | | ZHANG Lintao | Yunnan Engineering and Technology Center of Platinum-based Anti-tumor Drug,Kunming Guiyan Pharmaceutical Co.Ltd., Kunming 650106, China | | | WANG Yingfei | Yunnan Engineering and Technology Center of Platinum-based Anti-tumor Drug,Kunming Guiyan Pharmaceutical Co.Ltd., Kunming 650106, China | | | LIU Qixing | Yunnan Engineering and Technology Center of Platinum-based Anti-tumor Drug,Kunming Guiyan Pharmaceutical Co.Ltd., Kunming 650106, China | | | GUO Mingli | Yunnan Engineering and Technology Center of Platinum-based Anti-tumor Drug,Kunming Guiyan Pharmaceutical Co.Ltd., Kunming 650106, China | | | CHEN Hongjuan | Yunnan Engineering and Technology Center of Platinum-based Anti-tumor Drug,Kunming Guiyan Pharmaceutical Co.Ltd., Kunming 650106, China | | | PU Shaoping | Yunnan Engineering and Technology Center of Platinum-based Anti-tumor Drug,Kunming Guiyan Pharmaceutical Co.Ltd., Kunming 650106, China | pushaoping@163.com |
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| 中文摘要: |
| 通过水解法合成了甲基丙二酸-(反式-1，2-二甲胺基环丁烷)合铂(Ⅱ)。采用元素分析、质谱(ESI-MS)、红外光谱(IR)和核磁共振氢谱(1H NMR)确证了该配合物的组成和化学结构。采用MTS法评价其抗肿瘤活性，发现该配合物对常见5种癌细胞的生长有明显的抑制活性。 |
| 英文摘要: |
| Platinum compound was synthesized from potassium chloroplatinite, methylmalonic acid and trans-1,2-dimethylamine cyclobutane (or oxalate) by hydrolysis , named methyl malonic acid-[trans-1,2- dimethylamino cyclobutane] platinum(II) compound. It was analyzed by elemental analysis, ESI-MS, IR and 1H NMR. The structure and composition of the compound are consistent with the theory. MTS method was applied to evaluate its anti-tumor activity. The results showed that the compound has obvious inhibitory activity on the growth of Five common cancer cells. |
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