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| 顺式-二氯[(1R,2R)-(-)-环己二胺]合铂(Ⅱ)的合成与结构表征 |
| Synthesis and structural characterization of |
| Received:August 14, 2023 |
| DOI： |
| 中文关键词: 顺式-二氯[(1R,2R)-(-)-环己二胺]合铂 抗癌药物 合成 结构表征 |
| 英文关键词: cis-dichloro[(1R,2R)-(-)-cyclohexanediamine]platinum(Ⅱ) anticancer drug synthesis structural characterization |
| 基金项目:云南省基础研究专项面上项目(202001AT070090)；云南省技术创新人才项目((202305AD160019)；云南省转制科研院所技术开发研究专项(202104AR040016)；云南省科技计划项目(202102AB080007)；云南贵金属实验室科技计划项目(YPML- 2022050231) |
| Author Name | Affiliation | | GAO Anli | State key Laboratory of Advanced Technologies for Comprehensive Utilization of Platinum Metals,Kunming Institute of Precious Metals, Kunming 650106, China | | GUO Xuhu1 | State key Laboratory of Advanced Technologies for Comprehensive Utilization of Platinum Metals,Kunming Institute of Precious Metals, Kunming 650106, China | | YU Juan | State key Laboratory of Advanced Technologies for Comprehensive Utilization of Platinum Metals,Kunming Institute of Precious Metals, Kunming 650106, China | | ZHOU Peng | Department of Pharmacy, The Second Affiliated Hospital of Kunming Medical University, Kunming 650101, China
School of Pharmaceutical Science &Yunnan Key Laboratory of Pharmacology for Natural Products,Kunming Medical University, Kunming 650500, China |
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| 中文摘要: |
| 顺式-二氯[(1R,2R)-(-)-环己二胺]合铂是一种铂类抗癌药物及一种合成药效基团为(1R,2R)-(-)-环己二胺的铂类抗癌药物的中间体。通过两种常规方法合成了顺式-二氯[(1R,2R)-(-)-环己二胺]合铂，产率均高达90%以上，并采用元素分析、核磁共振谱、红外光谱及X-射线单晶衍射分析对其进行了结构表征。结果表明:此化合物的单晶结构含有1分子结晶水，为单斜晶系，C2空间群，晶胞参数为:a=12.753(3) nm，b=6.8749(16) nm，c=12.325(3) nm，α=90°，β=97.577(3)°，γ= 90°，V = 1071.1(4) nm3，Z=4，Pt-N键长分别为2.047和2.027 nm，Pt-Cl键长分别为2.326和2.330 nm，且Pt2+、N和Cl不在同一平面上，可能与结晶水、两个交错排列的分子间N-H...Cl氢键的存在有关。 |
| 英文摘要: |
| Cis-dichloro[(1R,2R)-(-)-cyclohexanediamine]platinum(Ⅱ) is an anticancer drug or an intermediate for the synthesis of many anticancer drugs with the carrier group (1R,2R)-(-) -cyclohexanediamine. It was synthesized by two conventional methods with a yield of above 90% and characterized by elemental analysis, 1H- and 13C- NMR, IR and X-ray single crystal diffraction analysis. The single-crystal structure cultivated by a solvent evaporation method contains one crystallization water molecule, belongs to monoclinic crystal system and C2 space group, the unit cell parameters are a=12.753 nm, b=6.8749 nm, c=12.325 nm, α=90°, β=97.577°, γ=90°, V=1071.1 nm3, Z = 4, Pd-N bond lengths are 2.047 and 2.027 nm as well as Pd-Cl are 2.326 and 2.330 nm, respectively, and Pt2+, N and Cl is not on the same plane, which may be due to the presence of one crystallization water molecule and N-H...Cl hydrogen-bond between two staggered molecules. |
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